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NF-B not only is involved in the proliferation and development of BC cells but also leads to resistance to some drugs used in cancer therapy such as anti-epidermal growth factor receptor (EGFR) drugs [62]

These have jeopardized the lives of millions of people throughout the world, particularly immunocompromised individuals

Results and discussion Primary fragment screening by X-ray crystallography Due to its broad affinity detection range (nanomolar to millimolar) and unique ability to initiate rational drug design 30 , we carried out a crystallographic fragment screen against TRF1 TRFH at the XChem facility of the Diamond Light Source 30

No published human pharmacokinetic data were identified by FDA